Spironolactone
Tamara see below-you can also go to pubmed and type in
spironolactone and acne for more articles. Traci
Muhlemann MF, Carter GD, Cream JJ, Wise P.
The effect of oral spironolactone (200 mg daily) on acne vulgaris
has been studied in 21 women in a randomized, placebo-controlled,
double-blind crossover study using 3 month treatment periods.
Compared with placebo, spironolactone produced significant
improvement as assessed by subjective benefit (P less than 0. 001),
number of inflamed lesions (P less than 0 . 001) and by an
independently evaluated photographic method (P less than 0 .02).
There was a fall in sex hormone binding globulin but no significant
changes in plasma testosterone and derived free testosterone.
Initial plasma androgen levels were no higher in responders than in
non-responders, nor did oral contraceptive use appear to affect
clinical response. Spironolactone is a useful alternative therapy
for women with acne vulgaris.
PMID: 2943311 [PubMed - indexed for MEDLINE]